CD300lf Conditional Knockout Mouse Reveals Strain-Specific Cellular Tropism of Murine Norovirus
نویسندگان
چکیده
Human noroviruses (HuNoVs) are a leading cause of gastroenteritis resulting in up to 200,000 deaths each year. The receptor and cell tropism HuNoV immunocompetent humans unclear.
منابع مشابه
Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells.
Norovirus is the leading cause of acute gastroenteritis worldwide. Since the discovery of human norovirus (HuNoV), an efficient and reproducible norovirus replication system has not been established in cultured cells. Although limited amounts of virus particles can be produced when the HuNoV genome is directly transfected into cells, the HuNoV cycle of infection has not been successfully reprod...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2021
ISSN: ['1098-5514', '1070-6321', '0022-538X']
DOI: https://doi.org/10.1128/jvi.01652-20